There is Twinvir no data on the effect of the drug on fetal development and lactation. During pregnancy and breastfeeding, the drug can be prescribed only by the therapist.

Pediatrics

The safety and efficacy of the combination of Ledipasvir and Sofosbuvir in patients under 18 years of age have not been studied.

Description

Twinvir ™ is available in the form of tablets for oral administration. The composition includes two active components: Ladipasvir, which is an inhibitor of the viral protein, and also Sofosbuvir, an inhibitor of the RNA polymerase.

Special Instructions

Bradycardia can occur in patients taking amiodarone, especially those who insufficiency of the final stage is calculated individually by the attending physician. The use of Twinvir ™ with other drugs containing Sofosbuvir is not recommended. Drug Interactions

Joint use of the drug with amiodarone can lead to bradycardia. P-gp inductors (rifampicin, rifabutin, St. John’s wort, carbmazepine, phenobarbital and phenytoin) lower the concentration of Ladipasvir and Sofosbuvir in the blood, which adversely affects the effectiveness of treatment.
Twinvir ™ is available in the form of tablets for oral administration. The composition includes two active components: Ladipasvir, which is an inhibitor of the viral protein, and also Sofosbuvir, an inhibitor of the RNA polymerase.